![]() The YSK12-C4 has both fusogenic and cationic properties. We report on the successful and efficient introduction of a siRNA targeting IDO1 into mouse DCs by a means of a multifunctional envelope-type nanodevice (MEND) containing a YSK12-C4 (YSK12-MEND). ![]() ![]() ![]() Silencing the IDO1 gene in DC by small interfering RNA (siRNA) represents a potent therapeutic strategy. However, activated DC express indoleamine 2,3-dioxygenase 1 (IDO1), a counter-regulatory and tolerogenic molecule, leading to the inhibition of T cell activation and the promotion of T cell differentiation into regulatory T cells. Cell-based therapy using dendritic cells (DC) represents a potent cancer immunotherapy.
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